Shorter wavelength light has been shown to be more effective than longer wavelengths in suppressing nocturnal melatonin and phase delaying the melatonin rhythm. In the present study, different wavelengths of light were evaluated for their capacity to phase advance the saliva melatonin rhythm. Two long wavelengths, 595 nm (amber) and 660 nm (red) and three shorter wavelengths, 470 nm (blue), 497 nm (blue/green), and 525 nm (green) were compared with a no-light control condition. Light was administered via a portable light source comprising two light-emitting diodes per eye, with the irradiance of each diode set at 65 microW/cm(2). Forty-two volunteers participated in up to six conditions resulting in 15 per condition. For the active light conditions, a 2-hr light pulse was administered from 06:00 hr on two consecutive mornings. Half-hourly saliva samples were collected on the evening prior to the first light pulse and the evening following the second light pulse. The time of melatonin onset was calculated for each night and the difference was calculated as a measure of phase advance. The shorter wavelengths of 470, 495 and 525 nm showed the greatest melatonin onset advances ranging from approximately 40-65 min while the longer wavelengths produced no significant phase advance. These results strengthen earlier findings that the human circadian system is more sensitive to the short wavelengths of light than the longer wavelengths.

中文翻译：

---

光波长在褪黑激素节律发展中的相位差异。

已经证明，在抑制夜间褪黑激素和相位延迟褪黑激素节律方面，较短波长的光比较长波长的光更有效。在本研究中，评估了不同波长的光对唾液褪黑激素节律的相位推进能力。将两个较长的波长595 nm（琥珀色）和660 nm（红色）和三个较短的波长470 nm（蓝色），497 nm（蓝色/绿色）和525 nm（绿色）与无光照条件进行了比较。通过每只眼睛包含两个发光二极管的便携式光源进行光照射，每个二极管的辐照度设置为65 microW / cm（2）。42名志愿者参加了多达6个条件，每个条件15个。对于活跃的光照条件，从连续两个早晨的06:00 hr开始进行2 hr的光脉冲。在第一个光脉冲之前的晚上和第二个光脉冲之后的晚上，每半小时收集一次唾液样本。计算每天晚上褪黑激素的发作时间，并计算差异作为相提前量。470、495和525 nm的较短波长显示褪黑激素起效最大，范围约为40-65分钟，而较长波长则未产生明显的相移。这些结果加强了先前的发现，即人体昼夜节律系统对短波长的光比长波长的光更敏感。470、495和525 nm的较短波长显示褪黑激素起效最大，范围约为40-65分钟，而较长波长则未产生明显的相移。这些结果加强了先前的发现，即人体昼夜节律系统对短波长的光比长波长的光更敏感。470、495和525 nm的较短波长显示褪黑激素起效最大，范围约为40-65分钟，而较长波长则未产生明显的相移。这些结果加强了先前的发现，即人体昼夜节律系统对短波长的光比长波长的光更敏感。