The yiaQRS genes of Escherichia coli K-12 are involved in carbohydrate metabolism. Clustering of homologous genes was found throughout several unrelated bacteria. Strikingly, all four bacterial transport protein classes were found, conserving transport function but not mechanism. It appears that during evolution the ability to transport, phosphorylate and metabolize substrates of unknown identity have been conserved. However, the transporter classes have been swapped. This probably demonstrates the subtlety of transport-protein evolution.

中文翻译：

---

转运蛋白的进化和碳水化合物代谢簇。

大肠杆菌K-12的yiaQRS基因参与碳水化合物的代谢。在几个不相关的细菌中发现了同源基因的簇。令人惊讶的是，发现了所有四个细菌转运蛋白类别，既保持了转运功能，又没有机制。似乎在进化过程中，转运，磷酸化和代谢身份未知的底物的能力已得到保留。但是，运输商类别已互换。这可能证明了转运蛋白进化的微妙之处。