Treatment of an open abdomen (OA) wound combined with an intestinal fistula is a challenge in the clinic. Here, inspired by the antibacterial activity of graphene (G) and its derivatives, we present a hybrid patch based on the ability of graphene and polycaprolactone (PCL) to kill bacteria and save the cells in a wound. Benefiting from the antibacterial ability of graphene oxide (GO), cells could survive in the presence of bacteria. With the increased ability to protect cells, this patch accelerated wound healing in an OA and intestinal fistula wound model. Additionally, the sub-acute toxicity score showed no extra damage to organs. In conclusion, the employment of the hybrid material for an OA and an intestinal fistula wound healing is encouraging. A hybrid patch based on graphene oxide and polycaprolactone electrospun was generated for open abdomen and fistula wound. The application of the hybrid patch could save the cells from bacteria which contribute to accelerating wound healing.

中文翻译：

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开放腹部的混合材料：从肠瘘中拯救伤口。

在临床上，开放性腹部（OA）伤口合并肠瘘的治疗是一个挑战。在这里，受石墨烯（G）及其衍生物的抗菌活性的启发，我们提出了一种基于石墨烯和聚己内酯（PCL）杀死细菌并将细胞保存在伤口中的能力的混合补丁。得益于氧化石墨烯（GO）的抗菌能力，细胞可以在细菌存在下存活。随着保护细胞能力的增强，该贴片可加速OA和肠瘘瘘管模型中的伤口愈合。另外，亚急性毒性评分显示对器官没有额外的损害。总之，将混合材料用于OA和肠瘘伤口愈合令人鼓舞。产生了基于氧化石墨烯和聚己内酯电纺丝的混合贴剂，用于开放腹部和瘘管伤口。杂种贴剂的应用可以使细胞免于细菌的侵害，而细菌有助于加速伤口的愈合。