MYOD is a master regulator of the skeletal myogenic program. But what regulates expression of Myod? More than 20 years ago, studies established that Myod expression is largely controlled by just two enhancer regions located within a region 24 kb upstream of the transcription start site in mammals, which regulate Myod expression in the embryo, fetus and adult. Despite this apparently simple arrangement, Myod regulation is complex, with different combinations of transcription factors acting on these enhancers in different muscle progenitor cells and phases of differentiation. A range of epigenetic modifications in the Myod upstream region also play a part in activating and repressing Myod expression during development and regeneration. Here the evidence for this binding at Myod control regions is summarized, giving an overview of our current understanding of Myod expression regulation in mammals.

中文翻译：

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主控制：哺乳动物Myod的转录调控。

MYOD是骨骼肌生成程序的主要调节器。但是什么调节了Myod的表达呢？20余年前，研究建立了MyoD的表达主要是由所处的区域在哺乳动物24 kb的转录起始位点上游内只有两个增强区域，从而调节控制MyoD的胚胎，胎儿和成人的表达。尽管这种看似简单的安排，但Myod调节却是复杂的，转录因子的不同组合作用于不同的肌肉祖细胞和分化阶段中的这些增强子。Myod上游区域的一系列表观遗传修饰也可激活和抑制Myod在发育和再生过程中表达。在这里总结了在Myod控制区域结合的证据，概述了我们目前对哺乳动物Myod表达调控的理解。