mTOR, the target of rapamycin, has been promoted as a potential target for cancers, transplantations and even lung fibrosis. However, paradoxically, targeting mTOR has been reported to result in profibrotic side effects. Some recent publications highlight why this might be.

中文翻译：

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靶向mTOR的药物会产生CCN2介导的纤维化副作用吗？

雷帕霉素的靶标mTOR已被推广为癌症，移植甚至肺纤维化的潜在靶标。然而，自相矛盾的是，已经报道了靶向mTOR导致纤维化副作用。最近的一些出版物强调了为什么会这样。