Angiogenesis is a critical, fine-tuned, multi-staged biological process. Tip-stalk cell selection and shuffling are the building blocks of sprouting angiogenesis. Accumulated evidences show that tip-stalk cell selection and shuffling are regulated by a variety of physical, chemical and biological factors, especially the interaction among multiple genes, their products and environments. The classic Notch-VEGFR, Slit-Robo, ECM-binding integrin, semaphorin and CCN family play important roles in tip-stalk cell selection and shuffling. In this review, we outline the progress and prospect in the mechanism and the roles of the various molecules and related signaling pathways in endothelial tip-stalk cell selection and shuffling. In the future, the regulators of tip-stalk cell selection and shuffling would be the potential markers and targets for angiogenesis.

中文翻译：

---

血管生成过程中内皮尖茎细胞的选择和改组。

血管生成是关键的，微调的，多阶段的生物过程。尖茎细胞的选择和改组是发芽血管生成的基础。积累的证据表明，茎秆细胞的选择和改组受多种物理，化学和生物学因素的调节，尤其是多个基因，它们的产物和环境之间的相互作用。经典的Notch-VEGFR，Slit-Robo，ECM结合整联蛋白，semaphorin和CCN家族在提示柄细胞选择和改组中起重要作用。在这篇综述中，我们概述了各种分子和相关信号通路在内皮尖茎细胞选择和改组中的作用机理和作用的进展和前景。在将来，