We present an electrically addressable optrode array capable of delivering light to 181 sites in the brain, each providing sufficient light to optogenetically excite thousands of neurons in vivo, developed with the aim to allow behavioral studies in large mammals. The device is a glass microneedle array directly integrated with a custom fabricated microLED device, which delivers light to 100 needle tips and 81 interstitial surface sites, giving two-level optogenetic excitation of neurons in vivo. Light delivery and thermal properties are evaluated, with the device capable of peak irradiances > 80    mW / mm 2 per needle site. The device consists of an array of 181 80    μ m × 80    μ m 2 microLEDs, fabricated on a 150 - μ m -thick GaN-on-sapphire wafer, coupled to a glass needle array on a 150 - μ m thick backplane. A pinhole layer is patterned on the sapphire side of the microLED array to reduce stray light. Future designs are explored through optical and thermal modeling and benchmarked against the current device.

中文翻译：

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用于神经接口的多站点microLED电极阵列。

我们提出了一种可电寻址的光极阵列，该阵列能够将光传送到大脑中的181个部位，每个部位都提供足够的光以光遗传学地激发体内成千上万的神经元，目的是为了进行大型哺乳动物的行为研究。该设备是玻璃微针阵列，直接与定制的microLED器件集成在一起，该器件可将光传递到100个针尖和81个间隙表面部位，从而在体内对神经元进行两级光遗传学激发。使用在每个针头位置能够达到的峰值辐照度> 80 mW / mm 2的设备，评估了光传输和热性能。该器件由181个80μm×80μm2 microLED阵列组成，该阵列在150μm厚的蓝宝石GaN晶片上制造，并与150μm厚的背板上的玻璃针阵列耦合。在microLED阵列的蓝宝石侧面上对针孔层进行构图，以减少杂散光。通过光学和热学建模探索未来的设计，并以当前器件为基准。