I argue here that polygenic scores are a public health hazard because the underlying methodology, genome wide association, from which they are derived, incorrectly assumes that the information encoded in the genomic DNA sequence is causal in terms of the cellular phenotype. This is not so when the cell is viewed from the perspective of a) fundamental physics, b) the protein chemistry that characterises the cellular cytoplasm and c) the fundamental requirement for evolution to yield unlimited species diversity.

中文翻译：

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多基因评分：它们是否对公共健康有害？

我在这里争论说，多基因评分是一种公共健康危害，因为从中得出基础方法学，全基因组关联会错误地假设基因组DNA序列中编码的信息在细胞表型方面具有因果关系。从a）基本物理学，b）表征细胞质的蛋白质化学以及c）产生无限物种多样性的进化的基本要求的角度来看，情况并非如此。