Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory loss and dementia. The pathological characteristics of AD include the deposition of amyloid beta (Aβ), neurofibrillary tangles, and neuronal loss. There is evidence showing the involvement of inflammation in AD, including activated microglia within and surrounding senile plaques. Epidemiological studies suggest the use of anti-inflammatory drugs to reduce incidence of AD. However, clinical trials with anti-inflammatory drugs have not been successful.

中文翻译：

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神经炎和抗炎治疗阿尔茨海默氏病的选择。

阿尔茨海默氏病（AD）是一种神经退行性疾病，其特征是进行性记忆丧失和痴呆。AD的病理特征包括β淀粉样蛋白（Aβ）的沉积，神经原纤维缠结和神经元丢失。有证据表明，AD参与了炎症反应，包括老年斑内和周围的小胶质细胞活化。流行病学研究表明，使用抗炎药可降低AD的发病率。但是，抗炎药的临床试验尚未成功。