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Two new lignans from the fruits of Forsythia suspensa.
Journal of Asian Natural Products Research ( IF 1.3 ) Pub Date : 2019-09-20 , DOI: 10.1080/10286020.2019.1666828
Jun Cao 1 , Si-Yuan Shao 1 , Xu Zhang 1 , Xiang Yuan 1 , Zi-Ming Feng 1 , Jian-Shuang Jiang 1 , Ya-Nan Yang 1 , Pei-Cheng Zhang 1
Affiliation  

Two new lignans, wikstronoside B (1) and forsysesquinorlignan (2), were isolated from the fruits of Forsythia suspensa, along with two known sesquineolignans, hedyotol A and hedyotol C (3 and 4). The structures of new compounds were established via extensive spectroscopy techniques, including UV, IR, HRESIMS, NMR, and ECD. Compounds 3 and 4 were isolated from this plant for the first time. Their anti-inflammatory effects were evaluated via a detection model with LPS-induced murine macrophage RAW264.7 cells, and compound 3 showed a moderate activity.

中文翻译:

连翘属植物果实中的两种新木脂素。

从连翘的果实中分离出两种新的木脂素,即维克茶苷B(1)和forsysesquinorlignan(2),以及两种已知的芝麻木脂素,七醇A和七醇C(3和4)。新化合物的结构是通过广泛的光谱技术建立的,包括UV,IR,HRESIMS,NMR和ECD。化合物3和4首次从该植物中分离出来。通过LPS诱导的鼠巨噬细胞RAW264.7细胞的检测模型评估了它们的抗炎作用,化合物3显示出中等活性。
更新日期:2020-04-20
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