Fluorescent nanoparticles are promising tools for living cancer cell imaging and cancer targeting. In this study, estrogen conjugated dye-doped fluorescent nanoparticles (estrogen conjugated FNPs) were synthesized and characterized. The functionalized nanoparticles with low toxicity have shown high selectivity and sensitivity toward target cells. Based on the specific recognition between the estrogen and the estrogen receptor, estrogen conjugated FNPs have been employed as optical probes for specific targeting of estrogen receptor-positive cancer cells with fluorescence microscopy imaging technology. The results demonstrate that the estrogen conjugated FNPs can effectively recognize breast cancer cells with good sensitivity and exceptional photostability, which would offer a novel approach for the diagnosis of breast cancer cells, as well as a new method in detecting estrogen receptors.

中文翻译：

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雌激素共轭荧光二氧化硅纳米粒子作为乳腺癌细胞成像的光学探针。

荧光纳米粒子是用于活癌细胞成像和癌症靶向的有前途的工具。在这项研究中，合成并表征了雌激素共轭的染料掺杂的荧光纳米粒子（雌激素共轭的FNP）。具有低毒性的功能化纳米颗粒对目标细胞显示出高选择性和敏感性。基于雌激素和雌激素受体之间的特异性识别，已使用雌激素缀合的FNP作为光学探针，通过荧光显微镜成像技术特异性靶向雌激素受体阳性癌细胞。结果表明，结合雌激素的FNP可以有效地识别乳腺癌细胞，具有良好的敏感性和出色的光稳定性，这将为诊断乳腺癌细胞提供一种新颖的方法，