The inflammatory cytokine, interleukin-2 (IL-2), is an important regulator of cellular functions. This relatively less studied member of the interleukin protein family is responsible for multiple immuno-modulatory and immuno-stimulatory tasks, like T cell activation, triggering of natural killer cells, inflammation, as well as proliferation and progression of autoimmune diseases and cancers. In this communication we report the temporally variant structural aspects of the IL-2 ligand and its receptor interfaces, based on the available crystal structures. The intended goal of this effort is to generate simulated results that could potentially aid the designs of novel structure based therapeutics.

中文翻译：

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使用生物信息学方法分析的炎性细胞因子白介素2的结构和功能。

炎性细胞因子白介素2（IL-2）是细胞功能的重要调节剂。白介素蛋白家族的这一研究相对较少的成员负责多种免疫调节和免疫刺激任务，例如T细胞活化，自然杀伤细胞触发，炎症以及自身免疫性疾病和癌症的增殖和发展。在此交流中，我们根据可用的晶体结构报告了IL-2配体及其受体界面的时变结构方面。这项工作的预期目标是生成模拟结果，这可能会有助于设计基于新型结构的疗法。