Lamtor1 is a lysosome-anchored protein that was first reported in 2009. In this review, we describe the discovery and intracellular functions of Lamtor1, as well as physiological roles of Lamtor1 in immune cells, namely, macrophages, CD4+ helper T-cells, and regulatory T-cells. To date, the following three strains of immune cell-specific conditional Lamtor1-knockout mice have been generated: myeloid-specific (LysM-Cre, Lamtor1flox), T-cell-specific (CD4-Cre, Lamtor1flox), and regulatory T-cell-specific (Foxp3-IRES-Cre, Lamtor1flox) knockout mice. The phenotypes observed in Lamtor1-knockouT-cells are partly mediated by decreased mTORC1 activity; however, lipid metabolism, including cholesterol biosynthesis and signaling via 25-hydroxycholesterol, is also involved. Therefore, Lamtor1 dynamically controls cellular function via mTORC1 activation and lipid signaling.

中文翻译：

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Lamtor1在巨噬细胞，CD4 + T细胞和调节性T细胞中的作用。

Lamtor1是一种溶酶体锚定蛋白，于2009年首次报道。在本综述中，我们描述Lamtor1的发现和细胞内功能，以及Lamtor1在免疫细胞中的生理作用，即巨噬细胞，CD4 +辅助性T细胞和调节性T细胞。迄今为止，已产生以下三种免疫细胞特异性条件性Lamtor1基因敲除小鼠株：髓样特异性（LysM-Cre，Lamtor1flox），T细胞特异性（CD4-Cre，Lamtor1flox）和调节性T细胞特异性（Foxp3-IRES-Cre，Lamtor1flox）敲除小鼠。在Lamtor1-knockouT细胞中观察到的表型部分由降低的mTORC1活性介导。但是，也涉及脂质代谢，包括胆固醇的生物合成和通过25-羟基胆固醇的信号传导。因此，