ABSTRACT Origin recognition complex (ORC), a heteromeric six-subunit complex, is the central component of the eukaryotic pre-replication complex. Recent data from yeast, frogs, flies and mammals present compelling evidence that ORC and its individual subunits have nonreplicative functions as well. The majority of these functions, such as heterochromatin formation, chromosome condensation, and segregation are dependent on ORC-DNA interactions. Furthermore, ORC is involved in the control of cell division via its participation in centrosome duplication and cytokinesis. Recent findings have also demonstrated a direct interaction between ORC and mRNPs and highlighted an essential role of ORC in mRNA nuclear export. Along with the growth of evolutionary complexity of organisms, ORC complex functions become more elaborate and new functions of the ORC sub-complexes and individual subunits have emerged.

中文翻译：

---

起源识别复合体的非复制功能


摘要 起源识别复合物（ORC）是一种异聚六亚基复合物，是真核生物复制前复合物的核心组成部分。来自酵母、青蛙、苍蝇和哺乳动物的最新数据提供了令人信服的证据，表明 ORC 及其各个亚基也具有非复制功能。大多数这些功能，例如异染色质形成、染色体浓缩和分离都依赖于 ORC-DNA 相互作用。此外，ORC 通过参与中心体复制和胞质分裂来参与细胞分裂的控制。最近的研究结果还证明了 ORC 和 mRNP 之间的直接相互作用，并强调了 ORC 在 mRNA 核输出中的重要作用。随着生物体进化复杂性的增长，ORC复合体的功能变得更加复杂，ORC子复合体和单个亚基的新功能不断出现。