This study assessed the feasibility of conducting 3 nonpharmacological interventions with older adults in dementia, exploring the effects of chair yoga (CY), compared to music intervention (MI) and chair-based exercise (CBE) in this population. Using a cluster randomized controlled trial (RCT), 3 community sites were randomly assigned 1:1:1 to CY, MI, or CBE. Participants attended twice-weekly 45-minute sessions for 12 weeks. Thirty-one participants were enrolled; 27 safely completed the interventions and final data collection (retention rate of 87%). Linear mixed modeling was performed to examine baseline and longitudinal group differences. The CY group improved significantly in quality of life compared to the MI group (CY mean = 35.6, standard deviation [SD] = 3.8; MI mean = 29.9, SD = 5.3, P = .010). However, no significant group differences were observed in physical function, behavioral, or psychological symptoms (eg, for mini-PPT: slopetime = 0.01, standard error [SE] = 0.3, P = .984 in the CBE group; slopetime = -0.1, SE = 0.3, P = .869 in the MI group; slopetime = -0.3, SE = 0.3, P = .361 in the CY group) over the 12-week intervention period. Overall, this pilot study is notable as the first cluster RCT of a range of nonpharmacological interventions to examine the feasibility of such interventions in older adults, most with moderate-to-severe dementia. Future clinical trials should be conducted to examine the effects of nonpharmacological interventions for older adults with dementia on health outcomes.

中文翻译：

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进行非药物干预措施来管理社区老年人痴呆症状的可行性：整群随机对照试验。


本研究评估了对痴呆症老年人进行 3 种非药物干预的可行性，探讨了椅子瑜伽 (CY) 与音乐干预 (MI) 和椅子运动 (CBE) 对该人群的影响。通过整群随机对照试验 (RCT)，3 个社区站点被随机分配为 CY、MI 或 CBE，比例为 1:1:1。参与者每周参加两次每次 45 分钟的课程，为期 12 周。登记了 31 名参与者； 27 人安全完成了干预和最终数据收集（保留率为 87%）。进行线性混合模型来检查基线和纵向组差异。与 MI 组相比，CY 组的生活质量显着改善（CY 平均值 = 35.6，标准差 [SD] = 3.8；MI 平均值 = 29.9，SD = 5.3，P = .010）。然而，在身体功能、行为或心理症状方面没有观察到显着的组间差异（例如，对于迷你 PPT：CBE 组的斜率时间 = 0.01，标准误差 [SE] = 0.3，P = .984；斜率时间 = -0.1在 12 周的干预期内，MI 组的 SE = 0.3，P = .869；CY 组的斜率时间 = -0.3，SE = 0.3，P = .361。总体而言，这项试点研究是值得注意的，它是一系列非药物干预措施的第一个集群随机对照试验，旨在检验此类干预措施对老年人（大多数患有中度至重度痴呆症）的可行性。未来应进行临床试验，以检查非药物干预对老年痴呆症患者健康结果的影响。