BACKGROUND Psoriasis is a common and intractable skin disease affecting the physical and mental health of patients. The accumulation of ROS is involved in the pathogenesis of psoriasis and antioxidants are believed to be therapeutic. This study aimed to investigate the therapeutic efficacy of astilbin on ROS accumulation in psoriasis. RESULTS The study showed that 50 μg/ml astilbin could inhibit the growth and reduce the accumulation of ROS in HaCaT cells stimulated by IL-17 and TNF-α. Astilbin could elevate the Nrf2 accumulation in the nuclei, eventually leading to the transcriptional activation of various antioxidant proteins and reducing the expression of VEGF. CONCLUSIONS Our results collectively suggest that astilbin could induce Nrf2 nucleus translocation, which is contribute to reduce the ROS accumulation and VEGF expression, and inhibit the proliferation of HaCaT cells.

中文翻译：

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在牛皮癣样皮肤病中，曲霉菌素通过Nrf2减少ROS积累和VEGF表达。

背景技术牛皮癣是一种常见且难治的皮肤疾病，其影响患者的身心健康。ROS的积累参与牛皮癣的发病机理，抗氧化剂被认为是治疗性的。这项研究的目的是调查在小鼠牛皮癣中，ASTLPIN对ROS累积的治疗效果。结果研究表明，在IL-17和TNF-α刺激下，HaCaT细胞中50μg/ ml的曲霉菌素可抑制其生长并减少ROS的积累。曲霉菌素可提高Nrf2在细胞核中的积累，最终导致各种抗氧化剂蛋白的转录激活并降低VEGF的表达。结论我们的研究结果共同表明，曲霉菌素可以诱导Nrf2核移位，这有助于减少ROS的积累和VEGF的表达，