Circadian rhythms are altered in Major Depressive Disorder (MDD) as showed by changes in circadian patterns of gene expression in the human brain of subjects affected by MDD (1). Circadian rhythms are produced centrally by clock genes and some single nucleotide polymorphisms located in clock genes have been associated with vulnerability to MDD (2). Similarly, one study suggests that clock gene expression in tissues related to pregnancy is altered in mice during pregnancy, although this has not been tested yet in humans (3). No data have been published thus far regarding the expression of clock genes during perinatal depression, while history of depression has been found to be associated with the increased expression of gene CLOCK that would be responsible for an anticipation of the sleep waking rhythms and of late insomnia typical in MDD. This article is protected by copyright. All rights reserved.

中文翻译：

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时钟基因在围产期抑郁症中的作用：黑暗中的光明

重度抑郁症 (MDD) 中的昼夜节律发生改变，如受 MDD 影响的受试者的人脑中基因表达的昼夜节律模式的变化所示 (1)。昼夜节律由时钟基因集中产生，位于时钟基因中的一些单核苷酸多态性与 MDD 的易感性有关 (2)。同样，一项研究表明，与怀孕相关的组织中的时钟基因表达在怀孕期间在小鼠中发生了改变，尽管尚未在人类中进行过测试 (3)。到目前为止，还没有关于围产期抑郁症期间时钟基因表达的数据发表，而发现抑郁症病史与基因 CLOCK 的表达增加有关，而 CLOCK 基因会导致预期的睡眠觉醒节律和晚期失眠MDD 中的典型。本文受版权保护。版权所有。