We performed this study to better elucidate the relationship between vascular endothelial growth factor (VEGF) polymorphisms and coronary heart disease (CHD). Eligible articles were searched in PubMed, Medline, Embase, Scopus and CNKI. A total of 24 studies containing 6489 CHD patients and 5664 control subjects were analyzed. Our overall and subgroup analyses suggested that rs699947 polymorphism was significantly associated with CHD susceptibility in both Caucasians and Asians, rs1570360 polymorphism was significantly associated with CHD susceptibility in Caucasians, and rs3025039 polymorphism was significantly associated with CHD susceptibility in Asians. Besides, rs3025039 polymorphism was significantly correlated with the number of affected coronary arteries, while rs699947 and rs2010963 polymorphisms were significantly correlated with poor collateral circulation in CHD patients. Overall, our findings indicate that VEGF rs699947, rs1570360, and rs3025039 polymorphisms may affect CHD susceptibility. Moreover, VEGF rs699947 and rs2010963 polymorphisms may serve as genetic biomarkers of poor collateral circulation after myocardial ischemia.

我们进行了这项研究，以更好地阐明血管内皮生长因子（VEGF）多态性与冠心病（CHD）之间的关系。在PubMed，Medline，Embase，Scopus和CNKI中搜索了符合条件的文章。总共分析了24个研究，其中包括6489位CHD患者和5664位对照受试者。我们的整体和亚组分析表明，rs699947多态性与白种人和亚洲人中的CHD易感性显着相关，rs1570360多态性与白种人中的CHD易感性显着相关，而rs3025039多态性与亚洲人中的CHD易感性显着相关。此外，rs3025039基因多态性与受影响的冠状动脉数量显着相关，rs699947和rs2010963基因多态性与冠心病患者侧支循环不良相关。总体而言，我们的发现表明VEGF rs699947，rs1570360和rs3025039多态性可能会影响CHD易感性。此外，VEGF rs699947和rs2010963的多态性可作为心肌缺血后侧支循环不良的遗传生物标记。