Fibroblast growth factor 21 (FGF21) is mainly secreted by the liver. It is a factor that is not fully understood in relation to growth. Sirtuin 1 (SIRT1) is a deacetylase protein. It is thought that may have an effect on the release and function of GH and IGF-1. Visfatin is synthesized from adipose tissue as primary. It may be prognostic marker associated with growth factors. As a result of our work, FGF21 is not associated with short stature but levels of SIRT1 and visfatin are associated with short stature. The decrease in visfatin value in the short-stature group is thought to be due to an insufficient amount of adipose tissue, which is important for growth and development. SIRT1 might decrease GH effect by increasing STAT5 deacetylation in the liver and we think that the result of this reduction of SIRT1 would negatively impact IGF-1 and IGFBP-3 production.

成纤维细胞生长因子21（FGF21）主要由肝脏分泌。关于增长，这是一个尚未完全理解的因素。Sirtuin 1（SIRT1）是一种脱乙酰基酶蛋白。认为可能对GH和IGF-1的释放和功能有影响。Visfatin是从脂肪组织合成的。它可能是与生长因子相关的预后指标。由于我们的工作，FGF21与身材矮小无关，但SIRT1和visfatin的水平与身材矮小有关。矮身材组的visfatin值下降被认为是由于脂肪组织不足，这对于生长和发育很重要。