All 5-hydroxytryptamine (5-HT; serotonin) receptors, except the 5-HT6 type, have been shown to be involved in cardiovascular regulation. In the periphery, 5-HT is stored in platelets, but the physiological role of 5-HT in the regulation of vascular tone (as opposed to its role in coagulation) remains unclear. However, central 5-HT1A, 5-HT3 and 5-HT7 receptors do play a physiological part in the regulation of cardiovascular reflexes, controlling changes in parasympathetic (vagal) drive to the heart. These reflexes also affect activity in the sympathetic nervous system, which itself can be inhibited by central 5-HT(1A) receptors to cause falls in blood pressure and excited by 5-HT2 receptors to cause rises in blood pressure. The physiological role of these receptors in the central regulation of the sympathetic nervous system is unclear, although 5-HT2 receptors could be involved in the development of deoxycorticosterone-acetate-salt hypertension, which is probably related to their role in the control of vasopressin release.

中文翻译：

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5-羟色胺和心血管调节。

除5-HT6类型外，所有5-羟色胺（5-HT； 5-羟色胺）受体均显示参与心血管调节。在外周，5-HT被储存在血小板中，但是5-HT在调节血管紧张方面的生理作用（与其在凝结中的作用相反）仍不清楚。但是，中枢5-HT1A，5-HT3和5-HT7受体确实在调节心血管反射，控制副交感神经（迷走神经）驱动心脏变化方面起着生理作用。这些反射还会影响交感神经系统的活动，而交感神经系统本身的活动可被中枢5-HT（1A）受体抑制从而导致血压下降，而被5-HT2受体激发而引起血压上升。这些受体在交感神经系统中枢调节中的生理作用尚不清楚，