Alpha1-adrenoceptors are G-protein-coupled receptors that bind catecholamines. Sixteen distinct human alpha1A-adrenoceptor isoforms have been identified from human tissues, including five full-length and 11 truncated versions. An updated scheme for the identification of alpha1A-adrenoceptor splice variants is proposed. Given the established roles of alpha1-adrenoceptors in benign prostatic hyperplasia, myocardial hypertrophy and other cardiovascular disorders, elucidation of the biological significance of the signaling diversity and potential pharmacological roles of alpha1A-adrenoceptor splice variants are important areas of future research.

中文翻译：

---

人类α1-肾上腺素受体亚型信号传导和基因组组织的更新。

Alpha1肾上腺素受体是与儿茶酚胺结合的G蛋白偶联受体。从人体组织中鉴定出16种不同的人alpha1A-肾上腺素受体同工型，包括5种全长和11种截短形式。提出了一种用于鉴定α1A-肾上腺素能受体剪接变体的更新方案。鉴于α1-肾上腺素受体在良性前列腺增生，心肌肥大和其他心血管疾病中已确立的作用，阐明信号多样性的生物学意义以及α1A-肾上腺素受体剪接变体的潜在药理作用是未来研究的重要领域。