G-protein-mediated signaling is the most widely used signaling mechanism in cells and its regulation is crucial for various physiological functions. G-protein-coupled receptor (GPCR) kinases (GRKs) are involved in the desensitization of GPCR signals. Recently, the X-ray crystal structure of GRK2 complexed with G beta gamma was demonstrated and revealed the intimate association of three important signaling modules with G beta gamma to regulate GRK2 activity.

中文翻译：

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GRK2-Gβγ复合体的结构：G蛋白信号传导模块的紧密联系。

G蛋白介导的信号传导是细胞中使用最广泛的信号传导机制，其调节对于各种生理功能至关重要。G蛋白偶联受体（GPCR）激酶（GRKs）参与了GPCR信号的脱敏。最近，展示了GRK2与Gβγ复合的X射线晶体结构，并揭示了三个重要的信号模块与Gβγ密切相关，以调节GRK2活性。