This article, adapted from our acceptance speech of the Avanti Award in Lipids at the 47th Biophysical Society meeting in San Antonio, 2003, summarizes over 30 years of research in the area of lipid bilayers. Beginning with a theoretical model of the phase transition (J.F.N.), we have proceeded experimentally using dilatometry and density centrifugation to study volume, differential scanning calorimetry to study heat capacity, and X-ray scattering techniques to study structure of lipid bilayers as a function of temperature. Electron density profiles of the gel and ripple phases have been obtained as well as profiles from several fluid phase lipids, which lead to many structural results that compliment molecular dynamics simulations from other groups. Using the theory of liquid crystallography plus oriented lipid samples, we are the first group to obtain both material parameters (KC and B) associated with the fluctuations in fluid phase lipids. This allows us to use fully hydrated lipid samples, as in vivo, to obtain the structure.

中文翻译：

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脂质双层：热力学，结构，波动和相互作用。

本文改编自2003年在圣安东尼奥举行的第47届生物物理学会会议上我们对脂质的阿凡提奖的接受感言，总结了脂质双分子层领域30多年来的研究。从相变（JFN）的理论模型开始，我们已经实验性地使用了膨胀计和密度离心法来研究体积，差示扫描量热法来研究热容量，并使用X射线散射技术来研究脂质双层的结构，该函数是温度。已经获得了凝胶相和波纹相的电子密度分布图，以及来自多个液相脂质的分布图，这导致了许多结构结果，这些结果与其他组的分子动力学模拟相辅相成。利用液晶色谱理论和定向脂质样品，我们是第一个获得与液相脂质波动相关的两种材料参数（KC和B）的小组。这使我们能够在体内使用完全水合的脂质样品来获得结构。