This work presents an analysis of the physicochemical interactions of natural and dimethylsilyl polyamines with an anionic deuterated phospholipid monolayer, d(62)DPPG (dipalmitoyl phosphatidyl glycerol), at the air-water interface. It was motivated by previous studies, which suggested an antitumour strategy based on the accumulation of derivatives such as bis(7-amino-4-azaheptyl) dimethylsilyl (azhepSi), in order to diminish the concentration of natural polyamines (spermine and putrescine) whose metabolism is strongly activated in tumour cells. Our results, obtained by the surface-pressure technique, Brewster angle microscopy (BAM) and polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS), support the idea of an interaction between the polar head groups of d(62)DPPG and amino groups followed by an adsorption of polyamines up to the carbonyl group. Moreover, an insertion of the dimethylsilyl group up to the alkyl chains occurs with azhepSi, in agreement with the observation that the cohesion of the alkyl chain is lower in this case, as compared with the effect of natural polyamines.

中文翻译：

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天然多胺和二甲基甲硅烷基类似物与磷脂单层的相互作用：通过布鲁斯特角显微镜和PM-IRRAS进行的研究。

这项工作提出了对天然和二甲基甲硅烷基多胺与阴离子氘代磷脂单层d（62）DPPG（二棕榈酰磷脂酰甘油）在空气-水界面处的物理化学相互作用的分析。它是由先前的研究激发的，该研究提出了基于诸如双（7-氨基-4-氮杂庚基）二甲基甲硅烷基（azhepSi）之类的衍生物积累的抗肿瘤策略，以减少其中肿瘤细胞中的新陈代谢被强烈激活。我们的结果是通过表面压力技术，布鲁斯特角显微镜（BAM）和偏振调制红外反射吸收光谱（PM-IRRAS）获得的，支持d（62）DPPG的极性头基团与氨基之间相互作用，然后吸附多胺直至羰基的想法。而且，与在自然情况下相比烷基链的内聚力较低的观察结果一致，在azepSi中，二甲基甲硅烷基基团一直插入到烷基链上。