Selenium supplementation in humans has been suggested for the prevention of chronic diseases including cardiovascular disease, cancer, and neurodegenerative diseases. Selenium biofortification of plants has been explored as a method for increasing selenium content of food and dietary selenium intake in humans. However, the effects of selenium biofortification on other dietary nutrients is often a secondary discussion. These effects are especially important to explore considering selenium-biofortified foods contain many other nutrients important to human health, such as other minerals and antioxidant compounds, which can make these foods superior to selenium supplementation alone. Investigation of selenium biofortification’s effect on these nutrients is necessary for a comprehensive human nutrition perspective on biofortification strategies. This review considers the effects of selenium biofortification on selenium content, other minerals, and antioxidant compounds as they pertain to human health in order to suggest optimal strategies for biofortification. Pre-clinical and clinical studies assessing the effects of consumption of selenium biofortified foods are also discussed.

中文翻译：

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硒对农作物的生物强化及其对人类健康和疾病预防重要的植物营养素和生物活性化合物的影响——综述

人体补充硒已被建议用于预防慢性疾病，包括心血管疾病、癌症和神经退行性疾病。已经探索了植物的硒生物强化作为增加食物中硒含量和人类膳食硒摄入量的方法。然而，硒生物强化对其他膳食营养素的影响通常是次要的讨论。考虑到硒生物强化食品含有许多其他对人类健康很重要的营养素，例如其他矿物质和抗氧化化合物，这些影响对于探索这些影响尤其重要，这些营养素可以使这些食品优于单独补充硒。研究硒生物强化对这些营养素的影响对于从人类营养角度全面了解生物强化策略是必要的。本综述考虑了硒生物强化对硒含量、其他矿物质和抗氧化化合物的影响，因为它们与人类健康有关，以提出生物强化的最佳策略。还讨论了评估硒生物强化食品消费影响的临床前和临床研究。