Self-referential cellular homeostasis is maintained by the measured assessment of both internal status and external conditions based within an integrated cellular information field. This cellular field attachment to biologic information space-time coordinates environmental inputs by connecting the cellular senome, as the sum of the sensory experiences of the cell, with its genome and epigenome. In multicellular organisms, individual cellular information fields aggregate into a collective information architectural matrix, termed a N-space Episenome, that enables mutualized organism-wide information management. It is hypothesized that biological organization represents a dual heritable system constituted by both its biological materiality and a conjoining N-space Episenome. It is further proposed that morphogenesis derives from reciprocations between these inter-related facets to yield coordinated multicellular growth and development. The N-space Episenome is conceived as a whole cell informational projection that is heritable, transferable via cell division and essential for the synchronous integration of the diverse self-referential cells that constitute holobionts.

通过在集成的蜂窝信息字段内对内部状态和外部条件进行测量评估，可以保持自我参照的细胞动态平衡。这种将细胞场附着于生物信息时空的方法是，通过连接细胞的基因组和表观基因组作为细胞的感官体验的总和，从而协调环境输入。在多细胞生物中，单个细胞信息字段聚集到一个称为N空间Episenome的集体信息体系结构矩阵中，该矩阵可实现整个生物体之间的相互信息管理。假设生物组织代表了一种双重遗传系统，既由其生物实质性又与相连的N空间Episenome。进一步提出形态发生源自这些相互关联的方面之间的往复运动，以产生协调的多细胞生长和发育。所述Ñ -space Episenome被看作是一全细胞信息投影即遗传的，转让通过细胞分裂和必不可少的构成holobionts多样化自我参照细胞的同步整合。