Normal growth and development of high plants strongly depends on the concentration of microelements, including essential heavy metals, in the substrate. However, an excess of those elements may become harmful. Therefore, micronutrient concentrations in plant tissue should be well-balanced and controlled by homeostatic mechanisms. The advancement of knowledge on the regulation of metal homeostasis in plants is important for phytoremediation of metal-contaminated soil and for micronutrient malnutrition control. Experimental data from loss-of-function and gain-of-function studies, including functional descriptions and classifications have presented new opportunities for multiplex CRISPR/dCas9-driven control of gene expression and have opened up new prospects for the goal-seeking regulation of metal homeostasis in plants. The aim of this review is to help for multiplex transcriptional programming targets search by summarizing and analyzing data on possible ways to handle a plant's ability to maintain metal homeostasis.

中文翻译：

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通过转基因和转录程序增强栽培植物对重金属胁迫的抗性的最新趋势。

高植物的正常生长和发育在很大程度上取决于基质中微量元素（包括必需的重金属）的浓度。但是，这些元素过多可能会有害。因此，植物组织中微量营养素的浓度应通过体内平衡机制得到很好的平衡和控制。关于植物体内金属稳态调节知识的发展对于金属污染土壤的植物修复和微量营养素的营养控制非常重要。来自功能丧失和功能获得研究的实验数据，包括功能描述和分类，为CRISPR / dCas9多重驱动的基因表达控制提供了新的机会，并为金属的寻靶调控开辟了新的前景植物体内的稳态。