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Techniques: fruit flies as models for neuropharmacological research.
Trends in Pharmacological Sciences ( IF 13.9 ) Pub Date : 2002-12-25 , DOI: 10.1016/s0165-6147(02)00004-4
Hari Manev 1 , Nikola Dimitrijevic , Svetlana Dzitoyeva
Affiliation  

An unlikely animal model is gaining popularity in neuropharmacological research: the 2-mm fruit fly (Drosophila melanogaster). Drugs have been administered to adult flies in their food and, more recently, via gasses and injections. Pharmacological tools have introduced behavioral alterations in Drosophila reminiscent of human behavior, rescued flies from gene-alteration-triggered neuropathologies, and triggered gene silencing. Combined, these methods hold promise for significant neuropharmacological advancement.

中文翻译:

技术:果蝇作为神经药理学研究的模型。

一种不太可能的动物模型在神经药理学研究中越来越受欢迎:2毫米果蝇(Drosophila melanogaster)。成年苍蝇已在其食物中以及最近通过毒气和注射向他们服用药物。药理学工具已在果蝇中引入了行为改变,让人联想到人类的行为,从基因改变触发的神经病理学中拯救了果蝇,并触发了基因沉默。结合起来,这些方法有望在神经药理学上取得重大进展。
更新日期:2019-11-01
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