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Galectin-3 is associated with severe heart failure and death: A hospital-based study in Chinese patients.
Scandinavian Journal of Immunology ( IF 4.1 ) Pub Date : 2020-03-05 , DOI: 10.1111/sji.12826 Na Wang 1 , Minyan Dang 2 , Wenzhi Zhang 2 , Yan Lei 2 , Zhaochuan Liu 3
Scandinavian Journal of Immunology ( IF 4.1 ) Pub Date : 2020-03-05 , DOI: 10.1111/sji.12826 Na Wang 1 , Minyan Dang 2 , Wenzhi Zhang 2 , Yan Lei 2 , Zhaochuan Liu 3
Affiliation
Heart failure (HF) is a serious disease syndrome characterized by elevated pro-inflammatory cytokines and inflammatory mediators presume to have significant contribution on disease progression. Galectins are carbohydrate-binding proteins responsible of various physiological functions. Role of galectins in heart failure has been ill-defined. In the present case-controls study, 136 patients clinically diagnosed with heart failure and 125 healthy Chinese controls were recruited. Levels of galectins (Gal-1, 3 and 9) and cytokines (IFN-γ, IL-17A, IL-4 and TGF-β) were quantified by ELISA. Increased levels of galectin-1 and 3 was observed in HF patients and associated with clinical severity. In addition, pro-inflammatory cytokines such as IFN-γ and IL-17A were increased in patients whereas, anti-inflammatory TGFβ was decreased. Galectin-3 was positively correlated with IFN-γ, IL-17A and inversely with TGF-β. Furthermore, ROC curve analysis suggested galectin-3 as a promising biomarker for diagnosis and HF and clinical severity. Interestingly, a two-year follow-up indicated significant association of elevated galectin-3 with mortality due to HF. In conclusion, galectin-3 associated with HF and clinical manifestations possibly by inducing pro-inflammatory cytokines and could be a possible biomarker of HF and severe clinical conditions.
更新日期：2020-03-05
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