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Emerging Therapies in the Treatment of Early Childhood Wheeze.
Pediatric Allergy, Immunology, and Pulmonology ( IF 0.9 ) Pub Date : 2019-06-17 , DOI: 10.1089/ped.2019.1043
Elissa M Abrams 1 , Hengameh H Raissy 2
Affiliation  

Phenotypic variation in asthma, especially early childhood asthma, is increasingly recognized. Although inhaled corticosteroids are recommended as first-line therapy, it has less efficacy in controlling intermittent wheeze due to viral-induced symptoms in early childhood. This article reviews 2 emerging therapies in particular for early childhood wheeze: azithromycin and bacterial lysate therapy. Azithromycin's effects are both antibacterial and anti-inflammatory, and it has been shown in 2 studies in preschoolers to prevent progression to severe respiratory tract infection and decrease duration of wheeze. Bacterial lysates work at multiple stages in the innate and adaptive immune response and have been shown to decrease mean wheeze duration in particular in the preschool age. More research is required although both therapies offer a promising future approach, in particular in the nonatopic preschool wheezer, as we move toward a more personalized approach to childhood asthma.

中文翻译:

早期治疗儿童喘息的新疗法。

哮喘,特别是儿童早期哮喘的表型变异日益得到认可。尽管推荐吸入皮质类固醇作为一线治疗方法,但由于儿童早期因病毒引起的症状,它在控制间歇性喘息方面疗效较差。本文回顾了2种新兴疗法,尤其是针对儿童早期喘息的疗法:阿奇霉素和细菌裂解液疗法。阿奇霉素的作用既有抗菌作用,又有消炎作用,在学龄前儿童中有2项研究表明,阿奇霉素可防止进展为严重的呼吸道感染并减少喘鸣的持续时间。细菌裂解物在先天性和适应性免疫反应的多个阶段起作用,并且已经显示出可以减少平均喘息持续时间,特别是在学龄前儿童。
更新日期:2019-11-01
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