Objective: To evaluate the early stage effects of adenoidectomy with/without tonsillectomy on immune functions in children aged <3 years. Methods: Twenty-four children aged <3 years underwent adenoidectomy with/without tonsillectomy were included. The levels of IgG, IgA, IgM, C3, and C4 were measured for humoral immunity, and the levels of CD3+, CD4+, CD8+, CD19+, CD56+, CD3+CD4-CD8-, and CD3+CD4+CD8+ T cells were measured for cellular immunity before and 2 weeks after the operation. Results: The postoperative levels of IgA, IgG, IgM, C3, and C4 were significantly increased compared with the preoperative levels (P < 0.05). The levels of CD3+, CD4+, CD8+, CD56+, CD3+CD4-CD8-, and CD3+CD4+CD8+ T cells were increased, while the level of CD19+ was decreased in postoperative period compared with preoperative period. Compared with those in the control group, the preoperative levels of IgA, IgG, and CD3+CD4+CD8+ T cells were significantly increased (P < 0.05), while the levels of IgM, C3, C4 and CD3+, CD4+, CD8+, CD56+, and CD3+CD4-CD8- T cells were not significantly changed. The postoperative levels of IgA, IgG, C3, C4, CD3+CD4-CD8-, and CD3+CD4+CD8+ T cells were significantly increased (P < 0.05), while the levels of IgM, CD3+, CD4+, CD8+, and CD56+ T cells were not significantly changed compared with those in the control group. Conclusion: Adenoidectomy with/without tonsillectomy could stimulate the immune responses, which could avoid significant immune deficiency in a short period of time in children aged <3 years.

中文翻译：

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有/没有扁桃体切除术的腺样体切除术对3岁以下儿童免疫功能的早期影响。

目的：评估有/无扁桃体切除腺样体切除术对3岁以下儿童免疫功能的早期影响。方法：包括24名<3岁的儿童，接受/不接受扁桃体切除术。测量IgG，IgA，IgM，C3和C4的体液免疫水平，并测量CD3 +，CD4 +，CD8 +，CD19 +，CD56 +，CD3 + CD4-CD8-和CD3 + CD4 + CD8 + T细胞的水平术前和术后2周进行细胞免疫检查。结果：术后IgA，IgG，IgM，C3和C4水平较术前明显升高（P <0.05）。与术前相比，术后3周CD3 +，CD4 +，CD8 +，CD56 +，CD3 + CD4-CD8-和CD3 + CD4 + CD8 + T细胞水平升高，而CD19 +水平降低。与对照组相比，术前IgA，IgG和CD3 + CD4 + CD8 + T细胞水平显着升高（P <0.05），而IgM，C3，C4和CD3 +，CD4 +，CD8 +，CD56 + ，和CD3 + CD4-CD8-T细胞没有明显改变。术后IgA，IgG，C3，C4，CD3 + CD4-CD8-和CD3 + CD4 + CD8 + T细胞水平显着增加（P <0.05），而IgM，CD3 +，CD4 +，CD8 +和CD56 +与对照组相比，T细胞没有明显改变。结论：有/无扁桃体切除术的腺样体切除术可以刺激免疫反应，可以避免3岁以下儿童在短时间内出现明显的免疫缺陷。IgM，C3，C4和CD3 +，CD4 +，CD8 +，CD56 +和CD3 + CD4-CD8- T细胞的水平没有明显变化。术后IgA，IgG，C3，C4，CD3 + CD4-CD8-和CD3 + CD4 + CD8 + T细胞水平显着增加（P <0.05），而IgM，CD3 +，CD4 +，CD8 +和CD56 +与对照组相比，T细胞没有明显改变。结论：有/无扁桃体切除术的腺样体切除术可以刺激免疫反应，可以避免3岁以下儿童在短时间内出现明显的免疫缺陷。IgM，C3，C4和CD3 +，CD4 +，CD8 +，CD56 +和CD3 + CD4-CD8- T细胞的水平没有明显变化。术后IgA，IgG，C3，C4，CD3 + CD4-CD8-和CD3 + CD4 + CD8 + T细胞水平显着增加（P <0.05），而IgM，CD3 +，CD4 +，CD8 +和CD56 +与对照组相比，T细胞没有明显改变。结论：有/无扁桃体切除术的腺样体切除术可以刺激免疫反应，可以避免3岁以下儿童在短时间内出现明显的免疫缺陷。CD56 + T细胞和CD56 + T细胞与对照组相比无明显变化。结论：有/无扁桃体切除术的腺样体切除术可以刺激免疫反应，可以避免3岁以下儿童在短时间内出现明显的免疫缺陷。CD56 + T细胞和CD56 + T细胞与对照组相比无明显变化。结论：有/无扁桃体切除术的腺样体切除术可以刺激免疫反应，可以避免3岁以下儿童在短时间内出现明显的免疫缺陷。