IncHI2-ST1 plasmids play an important role in co-mobilizing genes conferring resistance to critically important antibiotics and heavy metals. Here we present the identification and analysis of IncHI2-ST1 plasmid pSPRC-Echo1, isolated from an Enterobacter hormaechei strain from a Sydney hospital, which predates other multi-drug resistant IncHI2-ST1 plasmids reported from Australia. Our time-resolved phylogeny analysis indicates pSPRC-Echo1 represents a new lineage of IncHI2-ST1 plasmids and show how their diversification relates to the era of antibiotics.

中文翻译：

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在IncHI2-ST1质粒的系统发育多样性亚群中鉴定了新的质粒谱系。

IncHI2-ST1质粒在共同动员赋予对极为重要的抗生素和重金属的抗性的基因中起重要作用。在这里，我们介绍了从悉尼医院的霍曼肠杆菌菌株中分离的IncHI2-ST1质粒pSPRC-Echo1的鉴定和分析，该菌株早于澳大利亚报道的其他对多药耐药的IncHI2-ST1质粒。我们的时间分辨系统发育分析表明，pSPRC-Echo1代表了IncHI2-ST1质粒的新谱系，并显示了其多样化与抗生素时代的关系。