Phytophthora parasitica is an important oomycete that causes disease in a variety of plants, dimethomorph fungicides being specific for oomycetes. The aim of this study was to use RNA-seq to rapidly discover the mechanism by which dimethomorph acts in the treatment of P. parasitica. We found that the expression of 832 genes changed significantly after the dimethomorph treatment, including 365 up-regulated genes and 467 down-regulated genes. According to the Gene Ontology (GO) enrichment analysis, pathway enrichment and verification test results, the following conclusions are obtained: (i) the treatment of P. parasitica with dimethomorph causes changes in the expression levels of genes associated with the cell wall and cell wall synthesis; (ii) dimethomorph treatment results in reduced permeability of the cell membrane and changes in the expression of certain transport-related proteins; (iii) dimethomorph treatment increased reactive oxygen species and reduced the expression of genes related to the control of oxidative stress.

寄生疫霉（Phytophthora parasitica）是一种重要的卵菌，其在多种植物中引起疾病​​，乐果杀菌剂是卵菌特有的。这项研究的目的是使用RNA序列来快速发现乐果对寄生性疟原虫的作用机理。我们发现，乐果处理后832个基因的表达发生了显着变化，其中包括365个上调基因和467个下调基因。根据基因本体论（GO）富集分析，途径富集和验证测试结果，得出以下结论：（i）寄生性疟原虫的治疗甲吗啡引起与细胞壁和细胞壁合成有关的基因表达水平的改变；（ii）甲氧吗啡酮处理导致细胞膜通透性降低，某些运输相关蛋白的表达发生变化；（iii）乐果处理增加了活性氧的种类，并减少了与控制氧化应激有关的基因的表达。