The relationship between colorectal cancer and asbestos exposure has not been fully clarified. This study aimed to determine the associations between asbestos exposure and colorectal cancer. We performed a meta-analysis to quantitatively evaluate this association. A fixed effects model was used to summarize the relative risks across studies. Sources of heterogeneity were explored through subgroup analyses and meta-regression. We analyzed the dose-effect relationship using lung cancer standardized mortality ratio (SMR) and the risk of mesothelioma as a percent (%) as exposure surrogates. A total of 47 cohort studies were included. We identified 28 incidence cohort studies from 17 separate papers and extracted colorectal cancer standardized incidence ratio (SIR). Cancer mortality data were extracted from 19 separate cohorts among 13 papers. The overall colorectal cancer SMR for synthesis cohort was 1.07 (95% CI 1.02-1.12). Statistically significant excesses were observed in exposure to mixed asbestos (SMR/SIR=1.07), exposure to production (SMR/SIR=1.11), among asbestos cement workers (SMR/SIR=1.18) and asbestos textile workers (SMR/SIR=1.11). Additionally, we determined that the SMR for lung cancer increased with increased exposure to asbestos, as did the risk for colorectal cancer. This study confirms that colorectal cancer has a positive weak associations with asbestos exposure.

中文翻译：

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大肠癌和石棉暴露概述。

大肠癌与石棉暴露之间的关系尚未完全阐明。这项研究旨在确定石棉暴露与结直肠癌之间的关联。我们进行了荟萃分析以定量评估这种关联。固定效应模型用于总结研究之间的相对风险。通过亚组分析和元回归探索了异质性的来源。我们使用肺癌标准化死亡率（SMR）和间皮瘤风险（以百分比（％）作为替代指标）分析了剂量-效应关系。总共纳入了47个队列研究。我们从17篇单独的论文中确定了28个发病队列研究，并提取了结直肠癌标准化发病率（SIR）。癌症死亡率数据摘自13篇论文中的19个独立研究对象。合成队列的总结直肠癌SMR为1.07（95％CI 1.02-1.12）。在石棉水泥工人（SMR / SIR = 1.18）和石棉纺织工人（SMR / SIR = 1.11）中，混合石棉（SMR / SIR = 1.07），生产（SMR / SIR = 1.11），石棉水泥工人（SMR / SIR = 1.18）的暴露均具有统计学上的显着增加。 ）。此外，我们确定，随着石棉暴露量的增加，肺癌的SMR会增加，结直肠癌的风险也会增加。这项研究证实，结直肠癌与石棉接触具有弱的正相关性。此外，我们确定肺癌的SMR随着接触石棉的增加而增加，结直肠癌的风险也随之增加。这项研究证实，结直肠癌与石棉接触具有弱的正相关性。此外，我们确定肺癌的SMR随着接触石棉的增加而增加，结直肠癌的风险也随之增加。这项研究证实，结直肠癌与石棉接触具有弱的正相关性。