Objective: To characterize and compare the salivary microbiota in patients with pSS and patients with non-Sjögren’s-related sicca, and to relate the findings to their oral health status and saliva flow rates.

Methods: Twenty-four patients fulfilled the 2016 classification criteria for pSS and 34 did not (non-pSS). A clinical examination included registration of decayed, missing and filled teeth/-surfaces and collection of whole saliva. The microbiota was characterized using next-generation sequencing of the V1–V3 region of the 16S rRNA gene. Data were annotated against the eHOMD database.

Results: A total of 509 different bacterial taxa were identified. There were no statistically significant differences between the groups with regard to the abundance of predominant genera, bacterial diversity and relative abundance on the genus or species level. The two groups did not differ with regard to general health, including intake of xerogenic medication and polypharmacy, oral health status or unstimulated and stimulated whole saliva flow rates.

Conclusion: The salivary microbiota and oral health status, as well as salivary flow rate in patients with pSS resemble that of non-pSS patients. Our findings indicate that changes in the salivary microbiota do not appear to be determined by the disease entity pSS itself.

目的：鉴定和比较pSS患者和非Sjögren's Sicca患者的唾液菌群，并将其发现与口腔健康状况和唾液流速相关联。

方法：24名患者符合2016年pSS分类标准，而34名未达到（非pSS）标准。临床检查包括牙齿/表面腐烂，缺失和充满的记录以及整个唾液的收集。使用16S rRNA基因的V1-V3区域的下一代测序来表征菌群。数据是根据eHOMD数据库注释的。

结果：共鉴定到509个不同的细菌类群。在主要属的丰度，细菌多样性和属或种水平上的相对丰度方面，两组之间在统计学上没有显着差异。两组在总体健康方面没有差异，包括异种药物和多药的摄入，口腔健康状况或未刺激和刺激的整个唾液流速。

结论：pSS患者的唾液菌群和口腔健康状况以及唾液流速与非pSS患者相似。我们的发现表明，唾液微生物群的变化似乎不是由疾病实体pSS自身决定的。