BACKGROUND Mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have all been investigated as novel inflammatory markers of cardiac and oncological diseases, while there is only a limited number of studies investigating these markers in chronic obstructive pulmonary disease (COPD). In the present study we examine NLR, PLR; and other markers, such as eosinophil, MPV, plateletcrit (PCT), platelet distribution width (PDW), red cell distribution width (RDW), and C-reactive protein (CRP) in patients with stable and acute exacerbation of COPD. METHODS Stable COPD (Group 1, n=140), COPD with acute exacerbation (Group 2, n=110), and healthy controls (Group 3, n=50) were included in the study. Leukocyte, CRP, hemoglobin (HB), RDW, platelet, MPV, PCT, PDW, neutrophil, lymphocyte, eosinophil, NLR, and PLR were analyzed in all groups. RESULTS HB, leukocyte, platelet, neutrophil, eosinophil, MPV, PCT, CRP, NLR, and PLR were significantly higher, while the lymphocyte was lower in Group 1 than in Group 3. Leukocyte, neutrophil, RDW, CRP, NLR, and PLR were significantly higher, while lymphocyte was lower in Group 2 than in Group 3. Leukocyte, neutrophil, RDW, CRP, NLR, and PLR were significantly higher, while HB, platelet, MPV, PCT, and lymphocyte were significantly lower in Group 2 than in Group 1. NLR and PLR increased significantly in patients with bronchiectasis when compared to those without in Group 1. CONCLUSIONS Our study results suggest that NLR, PLR and RDW can be used as simple and cost-effective markers for the evaluation of severity of exacerbation and for predicting hospitalization and further exacerbations in patients with COPD.

中文翻译：

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慢性阻塞性肺疾病稳定和急性恶化患者的血清生物标志物：一项比较研究。


背景平均血小板体积（MPV）、中性粒细胞与淋巴细胞比率（NLR）和血小板与淋巴细胞比率（PLR）都已作为心脏和肿瘤疾病的新型炎症标志物进行了研究，但研究数量有限研究慢性阻塞性肺疾病（COPD）中的这些标志物。在本研究中，我们检查 NLR、PLR；慢性阻塞性肺病稳定急性加重患者的嗜酸性粒细胞、MPV、血小板压积（PCT）、血小板分布宽度（PDW）、红细胞分布宽度（RDW）和C反应蛋白（CRP）等其他标志物。方法 研究包括稳定 COPD（第 1 组，n=140）、慢性阻塞性肺病急性加重（第 2 组，n=110）和健康对照（第 3 组，n=50）。分析各组白细胞、CRP、血红蛋白（HB）、RDW、血小板、MPV、PCT、PDW、中性粒细胞、淋巴细胞、嗜酸性粒细胞、NLR、PLR。结果 组1的HB、白细胞、血小板、中性粒细胞、嗜酸性粒细胞、MPV、PCT、CRP、NLR、PLR显着升高，而淋巴细胞低于组3。白细胞、中性粒细胞、RDW、CRP、NLR、PLR第 2 组明显高于第 3 组，而淋巴细胞低于第 3 组。第 2 组白细胞、中性粒细胞、RDW、CRP、NLR 和 PLR 显着高于第 2 组，而 HB、血小板、MPV、PCT 和淋巴细胞显着低于第 3 组。第 1 组中。与第 1 组中没有支气管扩张的患者相比，有支气管扩张的患者的 NLR 和 PLR 显着增加。结论 我们的研究结果表明，NLR、PLR 和 RDW 可作为简单且经济有效的标志物来评估病情加重的严重程度以及预测 COPD 患者的住院情况和进一步恶化情况。