Environmental exposures to hazardous chemicals are associated with a variety of human diseases and disorders, including cancers. Phase I metabolic activation and detoxification reactions catalyzed by cytochrome P450 enzymes (CYPs) affect the toxicities of many xenobiotic compounds. Proper regulation of CYP expression influences their biological effects. Noncoding RNAs (ncRNAs) are involved in regulating CYP expression, and ncRNA expression is regulated in response to environmental chemicals. The mechanistic interactions between ncRNAs and CYPs associated with the toxicity and carcinogenicity of environmental chemicals are described in this review, focusing on microRNA-dependent CYP regulation. The role of long noncoding RNAs in regulating CYP expression is also presented and new avenues of research concerning this regulatory mechanism are described.

中文翻译：

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microRNA和长非编码RNA对细胞色素P450表达的调节：环境毒理学和致癌性的表观遗传机制。

危险化学品的环境暴露与各种人类疾病和病症有关，包括癌症。细胞色素P450酶（CYP）催化的I期代谢活化和解毒反应影响许多异源化合物的毒性。CYP表达的正确调节会影响其生物学效应。非编码RNA（ncRNA）参与调节CYP表达，并且ncRNA表达受环境化学物质的调节。ncRNA和CYP之间的机制相互作用与环境化学物质的毒性和致癌性有关，在本综述中进行了描述，重点关注依赖于microRNA的CYP调控。