Aim: To reduce the toxic effects and achieve efficiency of Tripterygium glycosides, an oral microemulsion was designed.

Method: After estimating its stability and characterisation, an animal experiment was held to evaluate its toxicity in vivo, using male and female Sprague Dawley rats.

Result: The maximum loading amount of microemulsion to Tripterygium glycosides was 18.87 mg/ml. And comparing to control, the Tripterygium glycoside microemulsion can maintain a normal level of the number of sperms, the weight of testicle, testosterone (∼2.5 ng/mL) and BUN (∼5 mmol/L) to male rats. For female rats, it can prevent the ovary to be atrophy and keep FSH to be stable (>2100 ng/L). The weaker injury induced by drug-loaded microemulsion to rats also could be observed in histological sections to kidney and reproductive organs.

Conclusions: Although the blank microemulsion had slight toxicity, it mitigated the toxicity of Tripterygium glycosides to kidney and reproductive system.

目的：为降低雷公藤多甙的毒性并提高其功效，设计了口服微乳。

方法：在评估了其稳定性和特性后，进行了一项动物实验，使用雄性和雌性Sprague Dawley大鼠评估其体内毒性。

结果：雷公藤多甙微乳剂的最大负载量为18.87 mg / ml。与对照组相比，雷公藤多甙微乳剂可以使雄性大鼠的精子数量，睾丸重量，睾丸激素（〜2.5 ng / mL）和BUN（〜5 mmol / L）保持正常水平。对于雌性大鼠，它可以防止卵巢萎缩并保持FSH稳定（> 2100 ng / L）。在肾脏和生殖器官的组织学切片中，也可以观察到载药微乳对大鼠的伤害较弱。

结论：尽管空白微乳具有轻微的毒性，但减轻了雷公藤多甙对肾脏和生殖系统的毒性。