当前位置: X-MOL 学术Arch. Immunol. Ther. Exp. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Significance and Role of Pattern Recognition Receptors in Malignancy.
Archivum Immunologiae et Therapiae Experimentalis ( IF 2.9 ) Pub Date : 2019-04-13 , DOI: 10.1007/s00005-019-00540-x
Jan Żeromski 1 , Mariusz Kaczmarek 1 , Maciej Boruczkowski 1 , Agata Kierepa 2 , Arleta Kowala-Piaskowska 2 , Iwona Mozer-Lisewska 2
Affiliation  

Pattern recognition receptors (PRRs) are members of innate immunity, playing pivotal role in several immunological reactions. They are known to act as a bridge between innate and adaptive immunity. They are expressed on several normal cell types but have been shown with increasing frequency on/in tumor cells. Significance of this phenomenon is largely unknown, but it has been shown by several authors that they, predominantly Toll-like receptors (TLRs), act in the interest of tumor, by promotion of its growth and spreading. Preparation of artificial of TLRs ligands (agonists) paved the way to use them as a therapeutic agents for cancer, so far in a limited scale. Agonists may be combined with conventional anti-cancer modalities with apparently promising results. PRRs recognizing nucleic acids such as RIG-1 like receptors (sensing RNA) and STING (sensing DNA) constitute a novel promising approach for cancer immunotherapy.

中文翻译:

模式识别受体在恶性肿瘤中的意义和作用。

模式识别受体(PRR)是先天免疫的成员,在几种免疫反应中起关键作用。众所周知,它们充当先天免疫和适应性免疫之间的桥梁。它们在几种正常细胞类型上表达,但在肿瘤细胞上/中的频率不断增加。这种现象的意义在很大程度上是未知的,但几位作者已经表明,它们主要是Toll样受体(TLR),通过促进肿瘤的生长和扩散而为肿瘤服务。迄今为止,人工制备TLRs配体(激动剂)为将其用作癌症治疗剂铺平了道路,目前规模有限。激动剂可以与常规的抗癌方式结合使用,具有明显的前景。
更新日期:2019-11-01
down
wechat
bug