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Atelo-collagen type I bovine bone substitute and membrane in guided bone regeneration: a series of clinical cases and histopathological assessments.
Histology and Histopathology ( IF 2.5 ) Pub Date : 2019-04-01 , DOI: 10.14670/hh-18-108
Ondine Lucaciu 1 , Dragos Apostu 2 , Alexandru Mester 1 , Radu Septimiu Campian 1 , Dan Gheban 3 , Richard J Miron 4
Affiliation  

Absorbable atelo-collagen type 1 represents a new approach for guided bone regeneration with several reported advantages such as: osteoblast attachment, proliferation, mineralization potential, absorption of growth factors and inhibition of bacterial pathogen colonization. The aim of this study was to assess the clinical, radiological (preoperative width, re-entry width, gain), Periotest measurements and histologic benefits of atelo-collagen-derived bovine bone grafts (ImploBone) in combination with an atelo-collagen type I barrier membrane (ImploSorb) for guided bone regeneration (GBR) of atrophic alveolar crest in thirteen patients. Eleven patients underwent simultaneous GBR with implant insertion, two had initial GBR procedure followed by implant placement after 6 months of healing. Ridge augmentation was performed using an atelo-collagen membrane (ImploSorb, Bioimplon, Germany) and a combination of 50% ABBM (ImploBone, granule size 0.5-1mm, BioImplon Germany) mixed with 50% autologous bone. It was found that simultaneous GBR with implant placement resulted in a 35% gain at bone defect level (preoperative width 5.03±1.25 mm, re-entry width 6.81±0.98 mm, gain 1.78±1.71 mm). Implant placement performed in a 2 stage surgery 6 months following GBR was linked with a 63,9% gain at bone defect level (preoperative width 3.79±1.10 mm, re-entry width 6.22±1.41 mm, gain 2.43±1.43 mm). The total gain in both groups was 41,9% utilizing these novel biomaterials (preoperative width 4.68±1.32 mm, re-entry width 6.65±1.12 mm, gain 1.96±1.64 mm). This case series study presents a protocol where GBR can be performed either simultaneously to implant placement or delayed with this innovative biomaterial to favor bone regrowth. Future randomized controlled clinical trials are needed to further validate the bone-promoting potential of atelo-collagen-based biomaterials for bone regeneration.

中文翻译:

Atelo-I型胶原蛋白牛骨替代物和膜在引导性骨再生中的作用:一系列临床病例和组织病理学评估。

可吸收的1型胶原蛋白代表了一种引导骨再生的新方法,具有一些已报道的优势,例如:成骨细胞附着,增殖,矿化潜力,生长因子的吸收和细菌病原体定植的抑制。这项研究的目的是评估结合Atelo-collagen I型的牛源于胶原蛋白的牛骨移植物(ImploBone)的临床,放射学(术前宽度,再进入宽度,增益),围岩期测量和组织学益处屏障膜(ImploSorb)用于13例萎缩性牙槽rest的引导性骨再生(GBR)。11例患者同时进行了GBR种植体植入,其中2例患者最初进行了GBR手术,并在6个月的愈合后植入了植入物。使用胶原蛋白膜(ImploSorb,Bioimplon,德国)和50%ABBM(ImploBone,颗粒大小0.5-1mm,BioImplon Germany)与50%自体骨混合的方法进行隆。结果发现,同时进行GBR和植入物植入可在骨缺损水平上获得35%的增益(术前宽度5.03±1.25 mm,再入宽度6.81±0.98 mm,增益1.78±1.71 mm)。GBR术后6个月在两阶段手术中进行的植入物植入与骨缺损水平增加63.9%(术前宽度3.79±1.10 mm,再入宽度6.22±1.41 mm,增加2.43±1.43 mm)有关。使用这些新型生物材料,两组的总增益为41.9%(术前宽度4.68±1.32 mm,再入宽度6.65±1.12 mm,增益1.96±1.64 mm)。该案例系列研究提出了一种方案,其中GBR可以同时进行植入物植入,也可以使用这种创新的生物材料延迟进行,以利于骨骼再生。需要进一步的随机对照临床试验,以进一步验证基于atelo-collagen的生物材料对骨骼再生的促进骨骼的潜力。
更新日期:2020-08-21
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