The objective of the current study was to propose a sensitivity analysis of a 3D left ventricle model in order to assess the influence of parameters on myocardial mechanical dispersion. A finite element model of LV electro-mechanical activity was proposed and a screening method was used to evaluate the sensitivity of model parameters on the standard deviation of time to peak strain. Results highlight the importance of propagation parameters associated with septal and lateral segments activation. Simulated curves were compared to myocardial strains, obtained from echocardiography of one healthy subject and one patient diagnosed with intraventricular dyssynchrony and coronary artery disease. Results show a close match between simulation and clinical strains and illustrate the model ability to reproduce myocardial strains in the context of intraventricular dyssynchrony.

中文翻译：

---

心室内不同步背景下左心室模型的敏感性分析

本研究的目的是提出 3D 左心室模型的敏感性分析，以评估参数对心肌机械分散的影响。提出了 LV 机电活动的有限元模型，并使用筛选方法评估模型参数对峰值应变时间标准偏差的敏感性。结果突出了与中隔和侧段激活相关的传播参数的重要性。将模拟曲线与从一名健康受试者和一名诊断为心室内不同步和冠状动脉疾病的患者的超声心动图获得的心肌应变进行比较。