It is well established that the vast majority of human RNA transcripts do not encode for proteins and that non-coding RNAs regulate cell physiology and shape cellular functions. A subset of them is involved in gene regulation at different levels, from epigenetic gene silencing to post-transcriptional regulation of mRNA stability. Notably, the aberrant expression of many non-coding RNAs has been associated with aggressive pathologies. Rapid advances in network biology indicates that the robustness of cellular processes is the result of specific properties of biological networks such as scale-free degree distribution and hierarchical modularity, suggesting that regulatory network analyses could provide new insights on gene regulation and dysfunction mechanisms. In this study we present an overview of public repositories where non-coding RNA-regulatory interactions are collected and annotated, we discuss unresolved questions for data integration and we recall existing resources to build and analyse networks.

中文翻译：

---

非编码RNA调控网络。

公认的是，绝大多数人类RNA转录本都不编码蛋白质，而非编码RNA则调节细胞生理并影响细胞功能。它们的一个子集以不同水平参与基因调节，从表观遗传基因沉默到转录后mRNA稳定性调节。值得注意的是，许多非编码RNA的异常表达与侵袭性病理有关。网络生物学的飞速发展表明，细胞过程的健壮性是生物网络特定特性（例如无标度分布和分层模块化）的结果，这表明调节网络分析可以提供有关基因调节和功能障碍机制的新见解。