This review will inevitably be influenced by my personal experience and personal view of the progression of this amazing family of proteins. This has generated a huge literature in over nearly five decades, some ideas have bloomed and faded while others have persisted, other contributions simply become redundant, overtaken by better techniques. At the outset, the pioneers had no idea of the magnitude of the topic they were working on, then a very rough idea of the significance emerged and, progressively, the picture becomes sharper and finally extraordinary. I have tried to produce at least an outline of that progression. My apologies for the also inevitable omissions, especially relating to the mass of biochemical and spectroscopy and genetical studies. I decided to prioritise structural biology because structures when successful are definitive and of course provide a 'visual' image. However, I tried to limit the structural aspects to the proteins that reflected the main advances.

中文翻译：

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ABC运输者家庭的兴起。

我的个人经历和对这一惊人蛋白质家族进程的个人见解将不可避免地影响到这篇评论。在近五十年的时间里，这已经产生了庞大的文学作品，有些思想蓬勃发展和衰落，而另一些思想坚持下来，其他思想变得多余，被更好的技术所取代。最初，先驱们不知道他们正在研究的主题的大小，然后就对意义的含义有了一个非常粗糙的想法，并且逐渐地，情况变得更加清晰，最终变得非凡。我试图至少对这种进展进行概述。对于同样不可避免的遗漏，我深表歉意，尤其是涉及大量的生物化学和光谱学以及遗传学研究。我决定优先考虑结构生物学，因为成功的结构是确定的，当然可以提供“视觉”图像。但是，我试图将结构方面的限制限于反映主要进展的蛋白质。