The yeast family Pichiaceae, also known as the 'methylotrophs clade', is a relatively little studied group of yeasts despite its economic and clinical relevance. To explore the genome evolution and synteny relationships within this family, we developed the Methylotroph Gene Order Browser (MGOB, http://mgob.ucd.ie) similar to our previous gene order browsers for other yeast families. The dataset contains genome sequences from nine Pichiaceae species, including our recent reference sequence of Pichia kudriavzevii. As an example, we demonstrate the conservation of synteny around the MOX1 locus among species both containing and lacking the MOX1 gene for methanol assimilation. We found ancient clusters of genes that are conserved as adjacent between Pichiaceae and Saccharomycetaceae. Surprisingly, we found evidence that the locations of some centromeres have been conserved among Pichiaceae species, and between Pichiaceae and Saccharomycetaceae, even though the centromeres fall into different structural categories-point centromeres, inverted repeats and retrotransposon cluster centromeres.

中文翻译：

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Methylotroph Gene Order Browser (MGOB) 揭示了酵母家族毕赤科中保守的同线和祖先着丝粒位置。

酵母家族 Pichiaceae，也被称为“甲基营养菌进化枝”，尽管它具有经济和临床相关性，但它是一个研究相对较少的酵母菌群。为了探索该家族内的基因组进化和同线性关系，我们开发了甲基营养基因顺序浏览器（MGOB，http://mgob.ucd.ie），类似于我们之前用于其他酵母家族的基因顺序浏览器。该数据集包含来自九个毕赤科物种的基因组序列，包括我们最近的 Pichia kudriavzevii 参考序列。例如，我们证明了在含有和缺乏用于甲醇同化的 MOX1 基因的物种中 MOX1 基因座周围的同线性保守性。我们发现古老的基因簇在 Pichiaceae 和 Saccharomycetaceae 之间是保守的。出奇，