The innate immune system-based recognition of the pathogens or their PAMPs initiates the pro-inflammatory immune response required for the maintenance of the homeostasis. The dysregulation of this innate immune response causes several diseases including sepsis, cancer and autoimmunity. However, pattern recognition receptors (PRRs) including toll-like receptors (TLRs), complement receptors (CRs) and NLRs of inflammasomes regulate both these processes of recognition of pathogens/PAMPs and their clearance. These three major components of the innate immune arm were studied independently/separately for a long time. Various studies have now shown that they work in close association and their crosstalk is required for the pathogen clearance via regulating the process of phagocytosis and mounting the controlled but potent immune response. The loss or inhibition of any of the three components affects the other in a positive/negative manner that can affect the immune process required for efficient host defense. The present review is designed to provide the current information on their evolution like the requirement of TLRs and inflammasomes for pathogen recognition even in the presence of complements system and their interaction during various immunological processes including phagocytosis, autophagy and inflammatory immune response.

对病原体或其PAMP的基于先天免疫系统的识别可引发维持体内稳态所需的促炎性免疫反应。这种先天免疫应答的失调会导致多种疾病，包括败血症，癌症和自身免疫。但是，模式识别受体（PRR）包括炎性小体的收费样受体（TLRs），补体受体（CRs）和NLRs调节病原体/ PAMPs的识别及其清除过程。长期以来，先天/后继研究了先天免疫臂的这三个主要成分。现在，各种研究表明它们密切相关，并且通过调节吞噬作用的过程并进行受控但有效的免疫反应，清除病原体需要串扰。三种成分中任何一种的丢失或抑制都会以正/负方式影响另一个，从而影响有效宿主防御所需的免疫过程。本综述旨在提供有关它们进化的最新信息，例如即使存在补体系统以及它们在包括吞噬作用，自噬和炎症免疫反应在内的各种免疫过程中的相互作用，也需要TLR和炎性小体来识别病原体。