DNA repair is a critical cellular process required for the maintenance of genomic integrity. It is now well appreciated that cells employ several DNA repair pathways to take care of distinct types of DNA damage. It is also well known that a cascade of signals namely DNA damage response or DDR is activated in response to DNA damage which comprise cellular responses, such as cell cycle arrest, DNA repair and cell death, if the damage is irreparable. There is also emerging literature suggesting a cross-talk between DNA damage signaling and several signaling networks within a cell. Moreover, cell death players themselves are also well known to engage in processes outside their canonical function of apoptosis. This chapter attempts to build a link between DNA damage, DDR and signaling from the studies mainly conducted in mammals and Drosophila model systems, with a special emphasis on their relevance in overall tissue homeostasis and development.

中文翻译：

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基因组损伤感应导致果蝇体内组织稳态。

DNA修复是维持基因组完整性所需的关键细胞过程。现在众所周知，细胞采用几种DNA修复途径来处理不同类型的DNA损伤。还众所周知的是，如果DNA损伤是无法修复的，则响应于DNA损伤而激活了一系列信号，即DNA损伤响应或DDR，DNA损伤包括细胞应答，例如细胞周期停滞，DNA修复和细胞死亡。也有新兴文献提出DNA损伤信号传导与细胞内多个信号传导网络之间的相互影响。此外，众所周知，细胞死亡参与者本身也参与细胞凋亡的典型功能之外的过程。本章试图在DNA损伤之间建立联系，