POTRA (for polypeptide-transport-associated domain) is a novel domain identified in proteins of the ShlB, Toc75, D15 and FtsQ/DivIB families. In most cases, the POTRA domain is associated with a beta-barrel outer membrane domain and its function has been experimentally related to polypeptide transport in Toc75 (Tic-Toc protein import system in chloroplast) and ShlB families. In addition to potential key roles in protein transport across the outer membrane and in bacterial septation, the POTRA domain has attractive features for vaccine development in diseases such as cholera, meningitis, gonorrhoea and syphilis.

中文翻译：

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POTRA：FtsQ家族中的保守结构域和一类β-桶外膜蛋白。

POTRA（与多肽运输相关的结构域）是在ShlB，Toc75，D15和FtsQ / DivIB家族的蛋白质中鉴定的新结构域。在大多数情况下，POTRA结构域与β-桶外膜结构域相关，并且其功能与Toc75（叶绿体中的Tic-Toc蛋白质输入系统）和ShlB家族中的多肽转运在实验上相关。除了在跨膜蛋白运输和细菌分离中的潜在关键作用外，POTRA结构域还具有针对霍乱，脑膜炎，淋病和梅毒等疾病的疫苗开发的吸引人的功能。