Chromatin remodeling enzymes rely on coenzymes derived from metabolic pathways, suggesting a tight synchronization among apparently diverse cellular processes. A unique example of this link is the recently described NAD(+)-dependent protein and/or histone deacetylases. The founding member of this family - yeast silent information regulator 2 (ySir2) - is involved in gene silencing, chromosomal stability and ageing. Sir2-like enzymes catalyze a reaction in which the cleavage of NAD(+)and histone and/or protein deacetylation are coupled to the formation of O-acetyl-ADP-ribose, a novel metabolite. The dependence of the reaction on both NAD(+) and the generation of this potential second messenger offers new clues to understanding the function and regulation of nuclear, cytoplasmic and mitochondrial Sir2-like enzymes.

中文翻译：

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关联染色质功能与代谢网络：Sir2家族的NAD（+）依赖性脱乙酰基酶。

染色质重塑酶依赖于从代谢途径衍生的辅酶，这表明明显不同的细胞过程之间存在紧密的同步。此链接的一个独特示例是最近描述的NAD（+）依赖性蛋白和/或组蛋白脱乙酰基酶。该家族的创始成员-酵母沉默信息调节剂2（ySir2）-参与基因沉默，染色体稳定性和衰老。类似于Sir2的酶催化一种反应，其中NAD（+）的裂解和组蛋白和/或蛋白质的脱乙酰作用与O-乙酰基-ADP-核糖（一种新型代谢物）的形成相关。反应对NAD（+）的依赖性以及该潜在第二信使的产生均提供了新的线索，以了解核，细胞质和线粒体Sir2样酶的功能和调控。