Abstract

The evolution in foodstuff-monitoring processes has increased the number of studies on biogenic amines (BAs), in recent years. This trend with future perspective needs to be assembled to address the associated health risks. Thus, this study aims to cover three main aspects of BAs: (i) occurrence, physiology, and toxicological effects, most probable formation mechanisms and factors controlling their growth; (ii) recent advances, strategies for determination, preconcentration steps, model technique, and nature of the matrix; and (iii) milestone, limitations with existing methodologies, future trends, and detailed expected developments for clinical use and on-site ultra-trace determination. The core of the ongoing review will discuss recent trends in pre-concentration toward miniaturization, automation, and possible coupling with electrochemical techniques, surface-enhanced Raman scattering, spectrofluorimetry, and lateral flow protocols to be exploited for the development of rapid, facile, and sensitive on-site determination strategies for BAs.

摘要

近年来，食品监控过程的发展增加了对生物胺的研究数量。需要结合这种具有未来前景的趋势来解决相关的健康风险。因此，本研究旨在涵盖BA的三个主要方面：（i）发生，生理和毒理作用，最可能的形成机制和控制其生长的因素；（ii）最新进展，确定策略，预浓缩步骤，模型技术和基质性质；（iii）里程碑，现有方法的局限性，未来趋势以及临床使用和现场超痕量测定的详细预期发展。持续审核的核心将讨论集中化朝着小型化，自动化，BA的现场确定策略。