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The Future of Gene-Guided Neuroscience Research in Non-Traditional Model Organisms.
Brain, Behavior and Evolution ( IF 2.1 ) Pub Date : 2019-08-15 , DOI: 10.1159/000500072
Scott Juntti 1
Affiliation  

Natural variations across animals in form, function, and behavior have long been sources of inspiration to scientists. Despite this, experimentalists focusing on the neural bases of behavior have increasingly focused on a select few model species. This consolidation is motivated primarily by the availability of resources and technologies for manipulation in these species. Recent years have witnessed a proliferation of experimental approaches that were developed primarily in traditional model species, but that may in principle be readily applied to any species. High-throughput sequencing, CRISPR gene editing, transgenesis, and other technologies have enabled new insights through their deployment in non-traditional model species. The availability of such approaches changes the calculation of which species to study, particularly when a trait of interest is most readily observed in a non-traditional model organism. If these technologies are widely adopted in many new species, it promises to revolutionize the field of neuroethology.

中文翻译:

非传统模型生物中基因指导的神经科学研究的未来。

长期以来,动物在形式,功能和行为上的自然变化一直是科学家的灵感来源。尽管如此,专注于行为的神经基础的实验者却越来越专注于少数几种模型物种。这种整合的主要动力是这些物种具有可操作的资源和技术。近年来,目睹了主要在传统模型物种中开发的实验方法的激增,但原则上可以容易地应用于任何物种。高通量测序,CRISPR基因编辑,转基因和其他技术已通过将其部署在非传统模型物种中而带来了新见解。这种方法的可用性改变了要研究的物种的计算,特别是在非传统模型生物中最容易观察到感兴趣的性状时。如果这些技术在许多新物种中得到广泛采用,它有望彻底改变神经行为学领域。
更新日期:2019-11-01
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